Yohimbine is an indole alkaloid derived from the bark of the Central African yohimbe tree (Pausinystalia yohimbe) that is widely used as therapy for erectile dysfunction. Yohimbine use has been associated with occasional severe adverse events, but has not been linked to serum enzyme elevations or clinically apparent acute liver injury.
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Active ingredient: |
yohimbine |
Molecular formula: |
C21H26N2O3 |
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Molecule weight： |
354.4427 |
CAS number: |
146-48-5 |
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Molecule structure： |
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The product is extracted from Yohimbe which is the name of the bark of a tall evergreen tree in western Africa known as Pausinystalia yohimbe or Corynanthe yohimbe. The bark has been used for centuries in some western African nations for sexual enhancement. It has been reported to contain up to 6% total alkaloids, 10-15% of which is yohimbine. In other words, a small percentage of a chemical called yohimbine is found in the bark of the yohimbe tree. Currently the extracts are sold in varying alkaloid concentrations, ranging from plain yohimbe bark powder, to 2% extract, 4%, 8%, 12 percent and up to 20% alkaloids.
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ANALYSIS |
SPECIFICATION |
RESULTS |
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Assay on dry basis |
Yohimbine≥8.0% |
8.12% HPLC |
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Organoleptic |
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Appearance |
Brown powder |
Complies |
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Odor |
Characteristic |
Complies |
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Part Used |
Bark |
Complies |
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Physical Characteristics |
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Particle Size |
NLT 98% through 80 mesh |
Complies |
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Solubility |
Slightly soluble in Water/Alcohol |
Complies |
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Loss on Drying |
≤5% |
2.26% |
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Residue on Ignition |
≤5% |
3.08% |
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Heavy Metal |
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Total Heavy Metal |
≤20ppm |
Complies |
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As |
≤2.0ppm |
Complies |
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Pb |
≤1.0ppm |
Complies |
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Cd |
≤1.0ppm |
Complies |
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Hg |
≤0.1ppm |
Complies |
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Microbiology |
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Total Plate Count |
≤1000cfu/g |
Complies |
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Yeast & Moulds |
≤100cfu/g |
Complies |
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E.Coli |
Negative |
Complies |
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Salmonella |
Negative |
Complies |
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S.aureus |
Negative |
Complies |
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ANALYSIS |
SPECIFICATION |
RESULTS |
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Assay on dry basis |
Yohimbine≥98% |
98.25% HPLC |
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Organoleptic |
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Appearance |
White fine powder |
Complies |
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Odor |
Characteristic |
Complies |
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Part Used |
Bark |
Complies |
|
Physical Characteristics |
||
|
Particle Size |
NLT 95% through 80 mesh |
Complies |
|
Solubility |
Slightly soluble in Water/Alcohol |
Complies |
|
Loss on Drying |
≤5% |
3.12% |
|
Residue on Ignition |
≤5% |
1.13% |
|
Heavy Metal |
||
|
Total Heavy Metal |
≤20ppm |
Complies |
|
As |
≤2.0ppm |
Complies |
|
Pb |
≤1.0ppm |
Complies |
|
Cd |
≤1.0ppm |
Complies |
|
Hg |
≤0.1ppm |
Complies |
|
Microbiology |
||
|
Total Plate Count |
≤1000cfu/g |
Complies |
|
Yeast & Moulds |
≤100cfu/g |
Complies |
|
E.Coli |
Negative |
Complies |
|
Salmonella |
Negative |
Complies |
|
S.aureus |
Negative |
Complies |
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1. Erectile Dysfunction
Yohimbine has been shown in several trials to help treat men with mild to moderate (rather than severe) erectile dysfunction. Yohimbine can increase blood flow and nerve impulses to the penis.
Recommended Dosage —— A mean dose of 0.4 mg/kg body weight or 30 mg daily, and a maximum of 50 mg, has been used in erectile dysfunction studies.
2. Obesity
Taking yohimbine along with a weight-loss diet can help people lost weight. The ability of yohimbine to stimulate the nervous system, and to promote the release of fat from fat cells, has led to claims that it might help weight loss by raising metabolic rate, reducing appetite, or increase fat burning.
Recommended Dosage —— 5 mg of yohimbine four times per day
3. Syncope/Orthostatic Hypotension
Orthostatic hypotension is a benign condition where, upon standing, lightheadedness results due to a temporarily reduced cerebral blood pressure. Yohimbine appears to be capable of enhancing sympathetic tone due to its ability to increase blood pressure.
Recommended Dosage —— 5 mg of yohimbine per day
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Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
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