Celastrol (tripterine) is a chemical compound isolated from the root of Tripterygium wilfordii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. The extract is used to make medicine.
Tripterygium wilfordii (Thunder God Vine) is a Traditional Chinese Medicine. Its root is used to make medicine. The usage of Thunder God Vine has centuries of history, and it also goes by other names like Huang-T’eng Ken, Lei Gong Teng, Lei-Kung T’eng, Taso-Ho-Hua, Threewingnut, Tonnerre de la Vigne de Dieu, Tripterigium Wilfordii, Tripterygium wilfordii, Vigne du Tonnerre Divin, and Yellow Vine. The vine is native to China, Japan, and Korea, and has been used for over 400 years for medicinal purposes in the area.
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ANALYSIS |
SPECIFICATION |
RESULTS |
|
Assay |
Triptolide≥98％ |
98.16% HPLC |
|
Appearance |
White Crystal Powder |
Complies |
|
Odor |
Characteristic |
Complies |
|
Taste |
Characteristic |
Complies |
|
Lost on drying |
≤5.0% |
1.18% |
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Ash Content |
≤2.00% |
0.49% |
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Mesh size |
NLT 98% through 80 mesh |
Complies |
|
Heavy metal |
≤10ppm |
Complies |
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Pb |
≤0.5ppm |
Complies |
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Arsenic |
≤2ppm |
Complies |
|
Total Bacteria |
≤1000cfu/g |
Complies |
|
Yeast Mold |
≤100cfu/g |
Complies |
|
Salmonella |
Negative |
Negative |
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E.Coli |
Negative |
Negative |
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Solvent Residences |
≤0.05% |
Complies |
1. Weight loss
Celastrol is a leptin sensitizer and a promising agent for the pharmacological treatment of obesity. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic dietinduced obese (DIO) mice by increasing leptin sensitivity. It clears the big obstacle of leptin resistance and recreats hopes for leptin-centric treatment of obesity.
2. Anti-inflammatory
Celastrol exhibits anti-inflammatory properties. It inhibits macrophage activation, MHC I and II processing, TNF-alpha, IL1, IL2, and IL6, it may be developed to be a new anti rheumatoid arthritis(RA) drug. It may be useful to minimize inflammation in Alzheimer's disease (AD).
3. Antioxidant
Celastrol is a powerful antioxidant, in an isolated rat liver assay of lipidperoxidation, celastrol had a 50% inhibitory cocentration of 7 μM, equivalent to about 15 times the antioxidant potency of a-tocopherol.
It should be noted that this plant has a very low therapeutic index (difference between the effective dose and the toxic dose) and that overdosing is both easy to do and critical; supplementation is usually avoided for this reason.
1. Rheumatoid arthritis
Taking thunder god vine extract seems to relieve joint pain and swelling and improve physical function in people with RA. It might help by relieving inflammation and by changing the way the immune system responds to the arthritis. Applying a liquid preparation (tincture) of thunder god vine to the skin over affected joints seems to decrease morning stiffness, and swelling.
Recommended dosage —— 180-360 mg of thunder god vine extract per day for up to 20 weeks; a tincture of thunder god vine applied over affected joints five to six times daily.
2. Male contraception
Taking thunder god vine extract might be effective as a male contraceptive. The chemical constituents in the extract appear to act primarily on sperm development (eg, sperm head-tail separation), with sperm returning to normal after 6 weeks; however, high quality clinical trials are lacking to confirm efficacy or safety.
Recommended dosage —— 20 to 30 mg of extract per day
3. Kidney problems (Nephrotic syndrome, Kidney transplant)
Some clinical trials have demonstrated positive effects of extracts in renal-associated conditions, such as renal transplant and nephrotic syndrome. Taking thunder god vine before a kidney transplant and for 5 years thereafter might prevent transplant rejection and improve survival in some people undergoing kidney transplantation. Early research suggests thunder god vine may be effective for nephrotic syndrome in children. The effects may be largely due to immune-modulation rather than direct activity on the kidney.
Recommended dosage —— For kidney problems (nephrotic syndrome) in children: 1 mg per kg of body weight daily for up to 20 weeks.
| By Express | By Air | By Sea |
|---|---|---|
| Suitable for under 50kg Fast: 7-15 days High cost Door to door service easy to pick up the goods |
Suitable for more than 50kg Fast: 7-15 days High cost Port to port professional broker needed |
Suitable for more than 500kg Slow: 7-45 days Low cost Port to port professional broker needed |
| Paypal(Suitable for under 500USD) | Alipay | Bank Transfer(Suitable for all amount) |
|---|---|---|
| 15% charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time:2-3 work days Easy to handle |
With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
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To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.