Niacinamide belongs to a form of vitamin B, also named nicotine amine, vitamin B3. It is an important derivative of niacin, widely existing in various organisms. Niacinamide can react with phosphoric acid, ribose and adenine to form coenzyme Ⅰ and coenzyme Ⅱ. And then it promotes proteins, fats, DNA synthesis and cell's energy metabolism. Therefore, it can effectively inhibit the melanin precipitation, weaken the color spots, and has a good whitening effect. At present, it is mainly used in whitening skin-care products and hair-care products.
|
Product Name |
Molecular Formula |
CAS Number |
Molecular Weight |
INCI Name |
Molecular Structure |
|
Niacinamide |
C6H6N2 O |
98-92-0 |
112.1g/mol |
Niacinamide |
|
Niacinamide is mainly produced by synthesis, which can be divided into chemical synthesis and biological synthesis.
Plamed adopts the biological method to produce Niacinamide, because the method is pollution-free and suitable for large-scale production to meet customers' needs.
|
|
Methods |
Advantages |
Disadvantages |
|
Chemical |
Use 3-methylpyridine directly to produce Niacinamide. |
Only one step to produce Niacinamide. The process is simple and the catalyst is easy to obtain. |
Serious environmental pollution, high consumption of raw materials, unstable production quality, difficult for large-scale production. |
|
Biological |
First produce 3-cyanopyridine using microbial catalyst, then hydrolyze 3-cyanopyridine to obtain Niacinamide. |
No pollution, high technical, low consumption of raw materials, stable product quality, suitable for large-scale industrial production. |
The process is relatively complex, but the science and technology progress can overcome the shortcoming. |
|
Items |
Specifications |
Result |
|
Assay |
≥99.0% |
99.4% |
|
Appearance |
White crystalline powder |
White crystalline powder |
|
Physical Characteristic |
||
|
Melting point |
128.0℃-131.0℃ |
130.0℃-131.0℃ |
|
Loss on Drying |
≤0.5% |
0.30% |
|
Residue on ignition |
≤0.1% |
0.05% |
|
Related substances |
≤0.5 |
≤0.4 |
|
Readily carbonized substance |
Conforms |
Conforms |
|
Clarity and color of solution |
Clear and colorless |
Clear and colorless |
|
Absorption coefficient |
E1 cm 1%: 417-443 |
437 |
|
pH |
5.5-7.5 (10% solution) |
5.8 |
|
Heavy Metal |
||
|
Total Heavy Metals |
≤20ppm |
Conforms |
1. Prevent melanin from precipitating into horny cells.
When melanin is transferred to horny cells, it will make skin darker. Niacinamide acts on the already produced melanin, and effectively inhibits the transmission of about 35% to 40% of melanin from melanin cells to keratinocytes. Thus it can reduce excessive melanin deposition. Clinical trials have shown that using niacinamide moisturizer can significantly diminish the area and number of brown spots on the skin.
2. Promote the melanin cells metabolism.
Nicotinamide can be absorbed by cells directly because of its small molecule. It can penetrate into the waterproof layer of skin's corneum within two hours, and act on the inner layer of skin. Applying nicotinamide to the skin can promote the formation of energy molecules in the body. And it passes through the cuticle layer to the dermal connective tissue and fiber. Then it directly reaches the bottom of the cell to promote cell metabolism.
3. Improve skin synthetic epidermal protein
Nicotinamide can synthesize protein on skin's surface. Thus it can improve skin texture and replenish moisture. In 1990, the European patent EP0-396-422 found that adding nicotinamide, sun-screening agents containing UVA, UVB and 0.1% ~ 5% silicone compound into cream formula, that can promote skin whitening and sun protection function.
Niacinamide is mainly used in cosmetics products of whitening, moisturizing, wrinkle and acne removal, and shampoo. It is usually mixed with fruit acid, salicylic acid, retinol, glycerol to prepare cosmetics. Adding it into shampoo can relieve itching and prevent hair loss.
|
Specification |
Reference Dosage |
|
Niacinamide 99% |
0.5%-2% |
Attention：
When the concentration of Niacinamide exceeds 5%, it is hard to be absorbed by the skin. Less than 5% amount will be effective for skin care. Therefore, the product should be added appropriately within the dosage range.
PH value of Niacinamide should be limited to 5~7. When pH value is below 5, it will be decomposed to niacin. Niacin can cause skin irritation.
Application cases of Nicotinamide in cosmetics at home and abroad:
|
Country |
Brand |
Product |
|
USA |
TruSkin Naturals |
Vitamin C-Plus Super Serum, Anti Aging Anti-Wrinkle Facial Serum |
|
The Ordinary |
Niacinamide 10% + Zinc 1% |
|
|
InstaNatural |
Niacinamide 5% Face Serum |
|
|
CeraVe |
Skin Renewing Night Cream, Sunscreen Face Lotion, Foaming Facial Cleanser |
|
|
Face n Earth, LLC |
Oil-Free Cream |
|
|
Olay |
Regenerist Regenerating Serum |
|
|
Body Merry |
Breakthrough Night Cream |
|
|
Dermedicine |
Natural Niacinamide Ultimate Strength Vitamin B Cream for Face |
|
|
LuxaDerme |
Brightening Bio Cellulose Face Sheet Mask |
|
|
Korea |
The Face Shop |
Anti Aging Serum |
|
Japan |
SK-Ⅱ |
Aura Essence |
|
France |
Cetaphil |
Body Moisturizer |
|
Bioderma |
Atoderm PP Balm |
Skin care lotion：
|
Ingredient |
Content（%） |
Ingredient |
Content（%） |
|
Niacinamide |
1.0 |
Glyceryl monostearate |
2.0 |
|
Stearic acid |
2.0 |
Spermol |
3.0 |
|
Cholesterol |
0.5 |
Vaseline |
2.0 |
|
Squalane |
10.0 |
Liquid paraffin |
10.0 |
|
Polydimethylsiloxane |
1.0 |
Methylparaben |
0.1 |
|
Butylparaben |
0.1 |
N-stearyl glutamic acid sodium |
1.0 |
|
Glycerin |
5.0 |
Propanediol |
3.0 |
|
Thallus laminariae PE |
1.0 |
Water |
Add to 100 |
Whitening cream：
|
Ingredient |
Content（%） |
Ingredient |
Content（%） |
|
Niacinamide |
3.20 |
Methylparaben |
0.15 |
|
Stearic acid |
16.00 |
Isopropyl palmitate |
4.40 |
|
PARSOL1789(Sun-screening agent) |
0.50 |
Fragrance |
0.20 |
|
PARSOLMCX(Sun-screening agent) |
1.20 |
Deionized water |
Add to 100.00 |
|
Dimethyl polysiloxane |
0.20 |
||
Shampoo：
|
Ingredient |
Content（%） |
Ingredient |
Content（%） |
|
Niacinamide |
0.1 |
D-panthenol |
0.25 |
|
Naphtha |
3.50 |
Hydroxypropyl methyl cellulose |
0.60 |
|
Mixed-alcohol |
4.80 |
Deionized water |
Add to100.00 |
|
Monostearin |
0.30 |
Sovermol(r)760 |
0.25 |
|
Polyglycerol/methyl glucose-distearate |
0.40 |
Methylparaben |
0.20 |
|
Cetyl-trimethyl ammonium chloride |
3.00 |
Propylparaben |
0.20 |
|
Glucose monohydrate |
2.00 |
Dehyquart(r)F75 |
0.35 |
| By Express | By Air | By Sea |
|---|---|---|
| Suitable for under 50kg Fast: 7-15 days High cost Door to door service easy to pick up the goods |
Suitable for more than 50kg Fast: 7-15 days High cost Port to port professional broker needed |
Suitable for more than 500kg Slow: 7-45 days Low cost Port to port professional broker needed |
| Paypal(Suitable for under 500USD) | Alipay | Bank Transfer(Suitable for all amount) |
|---|---|---|
| 15% charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time:2-3 work days Easy to handle |
With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
Where to buy Niacinamide? Where to find good Niacinamide Manufacturers and Niacinamide suppliers? Where can i Looking for Niacinamide purchase? Where can i purchase Niacinamide price and where to get Niacinamide for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Niacinamide. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.
