5-HTP (5-Hydroxytryptophan) is an amino acid. Amino acids are substances that build proteins in your body. It is also produced commercially from the seeds of an African plant (Griffonia simplicifolia). 5-HTP is related to serotonin, a brain chemical that affects mood, sleep, and pain. It is of the Pharmaceutical grade.
| Active ingredient: | 5-HTP | CAS Number: | 56-69-9 (114-03-4) |
| Molecular formula: | C11H12N2O3 | Molecular weight: | 220.23 |
| Molecular formula: |  |
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Most 5-HTP also known as oxitriptan (INN) is extracted from the seeds of a woody climbing shrub native to West Africa, called the Griffonia simplicifolia plant. It is the largest source of the compound 5-HTP. Its seeds contain up to 10-15% 5-HTP, by weight.
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ANALYSIS |
SPECIFICATION |
RESULTS |
Remark |
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Assay |
L-5-HTP≥20％ |
20.67% |
HPLC |
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Appearance |
Fine yellowish-brown powder |
Fine yellowish-brown powder |
Visual |
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Identification |
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Identification |
Retention time of L-5-HTP Peak matches with the L-5-HTP R.S |
Retention time of L-5-HTP Peak matches with the L-5-HTP R.S |
HPLC |
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Physical Characteristics |
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Particle size |
NLT 98% pass 80 mesh |
99% pass 80 mesh |
80 Mesh Screen |
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Loss of drying |
≤5.0% |
3.10% |
2~5g/105℃/5hrs |
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Residual on Ignition |
≤5.0% |
0.70% |
2g/525℃/3hrs |
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Impurity |
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Heavy Metal (As Pb) |
≤20ppm |
Complies |
Thioacetamide Colorimetric Method |
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As (As As2O3) |
≤3ppm |
Complies |
AAS |
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Lead (Pb) |
≤3ppm |
Complies |
AAS |
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Cadmium (Cd) |
≤1ppm |
Complies |
AAS |
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Mercury (Hg) |
≤0.11ppm |
Complies |
AAS |
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Aflatoxins |
≤10ppb |
Complies |
HPLC |
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Residual Solvents |
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Ethanol |
≤ 5000ppm |
Complies |
GC |
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Pesticides Solvents |
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Pesticides |
USP<561> |
Complies |
USP35 |
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Microbiological Characteristics |
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Total Plate Count |
<1000 cfu/g |
Complies |
GB 4789.2-2010 |
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Yeast and Mold |
<100 cfu/g |
Complies |
GB 4789.15-2010 |
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Coliforms |
<10 cfu/g |
Complies |
GB 4789.3-2010 |
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Escherichia Coli |
Negative |
Negative |
GB 4789.6-2010 |
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Salmonella enteritica |
Negative |
Negative |
GB 4789.4-2010 |
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Staphylococcus aureus |
Negative |
Negative |
GB 4789.2-2010 |
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ANALYSIS |
SPECIFICATION |
RESULTS |
Remark |
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Assay |
5-HTP≥98％ |
98.7% |
HPLC |
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Peak X |
Negative |
No Detected |
HPLC |
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Appearance |
White fine powder |
Conform |
Visual |
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Smell |
Characteristic odor |
Conform |
Scent |
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Loss on Drying |
≤ 5.0% |
1.50% |
5g/105℃/2hrs |
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Ash content |
≤ 1.0% |
0.35% |
5g/525℃/2hrs |
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Solvent residue |
≤500mg/kg |
33mg/kg |
GC |
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Sieve |
98% pass 80 mesh |
Conform |
80 mesh screen |
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Total Heavy Metals |
≤ 10ppm |
Conform |
CP2010 |
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Lead (Pb) |
≤ 1ppm |
0.35ppm |
CP2010(AAS) |
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Arsenic (As) |
≤ 1ppm |
0.11ppm |
CP2010(AAS) |
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Total Plate Count |
1000CFU/Gr. Max |
260CFU/Gr. |
CP2010 |
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Yeast& Mold |
100CFU/Gr. Max. |
10CFU/Gr. |
2CP2010 |
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E.Coli |
Negative |
Conform |
CP2010 |
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Salmonella |
Negative |
Conform |
CP2010 |
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ANALYSIS |
SPECIFICATION |
RESULTS |
Remark |
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Assay |
L-5-HTP≥99％ |
99.05% |
HPLC |
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Appearance |
Off-white powder |
Off-white powder |
Visual |
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Identification |
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Identification |
Retention time of L-5-HTP Peak matches with the L-5-HTP R.S |
Retention time of L-5-HTP Peak matches with the L-5-HTP R.S |
HPLC |
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Specific Rotation [a]D20 |
-32.5±2.0o(C=1, H2O) |
-32.5 |
C=1, H2O |
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Physical Characteristics |
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Particle size |
NLT 95% pass 80 mesh |
99% pass 80 mesh |
80 Mesh Screen |
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Loss of drying |
≤2.0% |
0.35% |
2~5g/105℃/5hrs |
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Residual on Ignition |
≤1.0% |
0.2% |
2g/525℃/3hrs |
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Impurity |
||||
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Heavy Metal (As Pb) |
≤20ppm |
Complies |
Thioacetamide Colorimetric Method |
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As (As As2O3) |
≤2ppm |
Complies |
AAS |
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Lead (Pb) |
≤2ppm |
Complies |
AAS |
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Cadmium (Cd) |
≤1ppm |
Complies |
AAS |
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Mercury (Hg) |
≤1ppm |
Complies |
AAS |
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Aflatoxins |
≤10ppb |
Complies |
HPLC |
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Residual Solvents |
||||
|
Ethanol |
USP<467> |
Complies |
USP35 |
|
|
Pesticides Solvents |
||||
|
Pesticides |
USP<561> |
Complies |
USP35 |
|
|
Microbiological Characteristics |
||||
|
Total Plate Count |
< 1000 cfu/g |
Complies |
GB 4789.2-2010 |
|
|
Yeast and Mold |
< 100 cfu/g |
Complies |
GB 4789.15-2010 |
|
|
Coliforms |
Negative |
Negative |
GB 4789.3-2010 |
|
|
Escherichia Coli |
Negative |
Negative |
GB 4789.6-2010 |
|
|
Salmonella enteritica |
Negative |
Negative |
GB 4789.4-2010 |
|
|
Staphylococcus aureus |
Negative |
Negative |
GB 4789.2-2010 |
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1. Depression
Some trials using 5-HTP with people suffering from depression indicate that 5-HTP may work as well as certain antidepressant drugs to treat people with mild-to-moderate depression. Depression has been linked to serotonin deficiency in the brain. Supplementing with 5-HTP may increase the levels of serotonin and reduce symptoms.
Recommended Dosage —— Several trials have found that doses of 100-300 mg daily for 2-4 weeks can improve symptoms of depression.
2. Fibromyalgia
Research suggests that 5-HTP can improve symptoms of fibromyalgia, including pain severity, morning stiffness, and sleeplessness. People with fibromyalgia often have low serotonin levels in their blood. Supplementation with 5-HTP may increase serotonin synthesis in these cases.
Recommended Dosage —— Several trials have reported that 5-HTP supplementation (100 mg three times per day) relieves some symptoms of fibromyalgia.
3. Insomnia
In one study, people who took 5-HTP went to sleep quicker and slept more deeply than those who took a placebo, presumably because it is converted to the chemical messenger, serotonin.
Recommended Dosage —— Researchers recommend 200 mg two hours before bedtime and 400 mg at bedtime for adult for 6 to 12 weeks, while for children with sleep terrors the recommended dosage is 3 mg/kg/day given at bedtime for 20 days.
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With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
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To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.