Phloretin is plant phenols with structure of dihydrochalcone. It can be found in the peel and root bark of succulent fruits, such as apple and pear, and in various vegetable juice. Plamed Phloretin is extracted from high quality apple peel. Phloretin has abundant biological activities including anti-oxidation, anti-tumor, blood sugar lowering, and protection of blood vessels. At the same time, it also has various cosmetic effects of anti-aging, whitening skin, anti-inflammatory, and anti-acne. It can dilute the pigmentation to whiten the skin, and the effect is better than Kojic Acid and Arbutin that are widely used as whitening agent.
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Active ingredient |
Phloretin |
CAS No. |
60-82-2 |
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Molecular formula |
C15H14O5 |
Molecular weight |
274.26 g/mol |
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Molecular structure |
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Apple (Latin name: Malus pumila) is favoured by most people, it's juicy and sweet. Apple tree is native to central Asia, and today it's cultivated worldwide. In China, it is mainly distributed in Shaanxi, Gansu, Shandong and Shanxi province. Apple is rich in carbohydrates, vitamins and trace elements. It is endowed with the name of “smart fruit” and “memory fruit”, which can be used for juicing and wine making. There's a saying "Apple a day keep doctor away".
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Items |
Specifications |
Results |
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Assay |
≥98% |
98.17% HPLC |
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Color |
white powder |
Conforms |
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Physical Characteristics |
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Particle Size |
100% through 80 mesh |
Conforms |
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Moisture |
≤1.00% |
0.63% |
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Ash Content |
≤1.00% |
0.16% |
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Heavy Metals |
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Heavy metals |
≤10.00ppm |
Conforms |
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Arsenic |
≤1.00ppm |
Conforms |
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Lead |
≤1.00ppm |
Conforms |
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Pesticide residues |
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Aflatoxin B1 |
≤5.00ug/kg |
Conforms |
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Solvent residences |
≤0.05% |
Conforms |
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666(BHC) |
≤0.10ppm |
Conforms |
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DDT |
≤0.10ppm |
Conforms |
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PCNB |
≤0.10ppm |
Conforms |
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Aldrin |
≤0.02ppm |
Conforms |
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Microbiological Tests |
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Total Plate count |
≤1000cfu/g |
Conforms |
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Yeast & mold |
≤100cfu/g |
Conforms |
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E. coli |
Negative |
Negative |
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Salmonella |
Negative |
Negative |
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Staphylococcus |
Negative |
Negative |
1. Skin whitening
Phloretin has an inhibitory effect on tyrosinase activity, and the IC50 (half maximal inhibitory concentration) is 37.5 μmol/L. A study found that 0.3% Phloretin inhibited tyrosinase by up to 98.2%, and its IC50 is 0.05%. It has better inhibitory on tyrosinase than Kojic Acid and Arbutin. Further studies found that the combination of Phloretin and a common tyrosinase inhibitor can greatly increase its inhibition rate on tyrosinase and achieve a 100% inhibition effect.
2. Anti-inflammatory and anti-bacteria
Studies have shown that Phloretin has anti-inflammatory effect, because it can inhibit the production of inflammatory factors, chemokines and differentiation factors. It can inhibit monocytes to adhere to keratinocytes and block the phosphorylation of the signaling protein kinases Akt and MAPK to achieve anti-inflammatory effects. Also, Phloretin is able to inhibit bacterias. On the one hand, it affects the energy metabolism of bacteria and the oxidative damage repair of bacterial growth; on the other hand, it leads to bacterial death by interfering with the synthesis of proteins inside the cells and disordering the metabolism inside the cells.
3. Sunscreen
It has been found that Phloretin can not only directly absorb ultraviolet rays, but also reduce the damage of ultraviolet light to keratinocytes. It increases the SPF and SPA values of the cosmetic to add Phloretin. In addition, combination of Phloretin, VC and Ferulic Acid protects human skin from UV rays.
4. Anti-oxidation and anti-aging
Vitro experiments showed that Phloretin has the ability to inhibit peroxidation of mitochondrial lipid as well as scavenge DPPH free radical and ABTS free radicals. The antioxidant concentration to lipids is 10.30mg/L, which can remove free radicals in the skin. Phloretin not only has its own antioxidant effect, but also can be combined with other antioxidants to improve the antioxidant effect.
5. Moisturize skin
In recent years, researchers have found that plant-derived compounds have effect to moisturize skin, for example plant polysaccharides, plant polyphenols, and the like having a polar group like a hydroxyl group or a carboxyl group. The four hydroxyl groups contained in Phloretin bonds with water molecules to form hydrogen bond to absorb moisture. Therefore, Phloretin can also be used as a natural moisturizer in cosmetics.
6. Prevent hair loss
Soybean lipoxygenase is one of the important enzymes in the process of lipid oxidation; it affects hair loss. Foreign studies have shown that Phloretin can inhibit the activity of soybean lipoxygenase, thereby reducing hair loss due to premature aging. So Phloretin has potential anti-hair loss effect. It can be added as a raw material for anti-hair loss to shampoo and hair care products.
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|---|---|---|
| Suitable for under 50kg Fast: 7-15 days High cost Door to door service easy to pick up the goods |
Suitable for more than 50kg Fast: 7-15 days High cost Port to port professional broker needed |
Suitable for more than 500kg Slow: 7-45 days Low cost Port to port professional broker needed |
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With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
Where to buy Phloretin? Where to find good Phloretin Manufacturers and Phloretin suppliers? Where can i Looking for Phloretin purchase? Where can i purchase Phloretin price and where to get Phloretin for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Phloretin. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.
