Hyaluronic Acid is a member of the family of molecules known as glycosaminoglycans. It is a substance that is naturally present in the human body. It is found in the highest concentrations in fluids in the eyes and joints. Hyaluronic Acid used as medicine is extracted from rooster combs or made by bacteria in the laboratory. Hyaluronic Acid's water solution has a very high moisture retention, viscoelasticity and lubricity. Hyaluronic Acid can be widely used in cosmetics, pharmaceuticals, health food and other industries.
Hyaluronic Acid on the market is usually its sodium form, that is Sodium Hyaluronate. Sodium Hyaluronate is usually called as Hyaluronic Acid.
| Active ingredient: | Hyaluronic acid | CAS Number: | 9004-61-9 |
| Molecular formula: | (C14H21NO11)n | Molecular structure: |  |
Hyaluronic Acid can be widely found in nature. It is a component of extracellular matrix. It exists in the connective tissue of mammals, joint synovial fluid, skin, ocular vitreous body, umbilical cord. combs, whale cartilage, shark skin, seaweed and mollusc.
In commercial manufacture, Microbial Fermentation is widely adopted. Hyaluronic Acid is fermented from the mutant of Streptococcus zooepidemics.
|
Items |
Specifications |
Results |
|
Molecular weight |
≤6×105 Dalton |
5.83×105 Dalton |
|
Glucuronic acid |
≥44% |
45.80% |
|
Protein |
≤0.05% |
0.026% |
|
PH |
6.0-7.5 |
6.6 |
|
Dynamite viscosity |
/ |
18.43mm2/s |
|
Appearance |
White powder |
Conforms |
|
Physical Characteristics |
||
|
Transparency (0.1% solution) |
≥99.0% |
99.96% |
|
Moisture |
≤10.0% |
8.27% |
|
Ash Content |
≤20.0% |
12.00% |
|
Heavy Metals |
||
|
Heavy metals |
≤10ppm |
Conforms |
|
Microbiological Tests |
||
|
Total Plate count |
≤100cfu/g |
30cfu/g |
|
Items |
Specifications |
Results |
|
Molecular weight |
6-14×105 Dalton |
13.3×105 Dalton |
|
Glucuronic acid |
≥44% |
46.20% |
|
Protein |
≤0.05% |
0.02% |
|
PH |
6.0-7.5 |
6.2 |
|
Dynamite viscosity |
/ |
45.70mm2/s |
|
Appearance |
White powder |
Conforms |
|
Physical Characteristics |
||
|
Transparency (0.1% solution) |
≥99.0% |
99.8% |
|
Moisture |
≤10.0% |
8.27% |
|
Ash Content |
≤13.0% |
11.30% |
|
Heavy Metals |
||
|
Heavy metals |
≤10ppm |
Conforms |
|
Microbiological Tests |
||
|
Total Plate count |
≤100cfu/g |
30cfu/g |
|
Yeast & mold |
≤100cfu/g |
Conforms |
|
Escherichia coli |
Negative |
Negative |
|
Staphylococcus |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
|
Items |
Specifications |
Results |
|
Molecular weight |
≥14×105 Dalton |
15.10×105 Dalton |
|
Glucuronic acid |
≥44% |
46.10% |
|
Protein |
≤0.05% |
0.020% |
|
PH |
6.0-7.5 |
6.7 |
|
Dynamite viscosity |
/ |
52.23mm2/s |
|
Appearance |
White powder |
Conforms |
|
Physical Characteristics |
||
|
Transparency (0.1% solution) |
≥99.0% |
99.90% |
|
Moisture |
≤10.0% |
8.12% |
|
Ash Content |
≤20.0% |
11.80% |
|
Heavy Metals |
||
|
Heavy metals |
≤10ppm |
Conforms |
|
Microbiological Tests |
||
|
Total Plate count |
≤100cfu/g |
20cfu/g |
Raw material→Fermentation→Extract→Separation→Dry→Smash and sieve→Package
1. Skin care
Hyaluronic Acid can heal dryness when applied to face. Hyaluronic Acid holds up to 1,000 times its weight in water. It draws moisture out of the environment and forms a protective, hydrating barrier on the skin.
Some research suggests that injecting a specific hyaluronic acid product (Perlane) into the skin can help smooth moderate to severe facial folds and wrinkles. Perlane attracts and binds water molecules to help smooth away wrinkles and folds. The injection should be done by a healthcare provider with an ultrafine needle.
Topical application of hyaluronic acid gel can improve skin healing.
2. Osteoarthritis
Injection of hyaluronic acid compounds into osteoarthritic joints, primarily the knee, has been shown to reduce stiffness and joint pain. Hyaluronic Acid is an important constituent of joint fluid, where it serves as a cushion and lubricant and plays a role in resisting compressive forces, but its amount and molecular structure are altered in osteoarthritic joints.
3. Eye problems
Hyaluronic acid is a major ingredient of the vitreous humor that fills the inner chamber of the eye. So it can be used to treat some eye problems.
Injecting hyaluronic acid into the eye is effective when used during cataract surgery by an eye surgeon.
Some research shows that applying a specific hyaluronic acid eye drop might relieve dry eye.
Some research suggests that hyaluronic acid might be injected into the eye to treat detached retina or other eye injuries.
4. Gingivitis
Hyaluronic acid is an important connective tissue component in the gums. Topical hyaluronic acid treatments (gels and sprays containing hyaluronic acid) have been shown to help reduce bleeding tendency and other indicators of gingivitis.
1. Skin care products
| Skin care products | Molecular weight | Amount Suggested | Effect |
| Toner, facial cleanser, mask | ≤6×105 Dalton | 0.1% |
Penetrate into dermis to moisturize skin, promote skin absorption of nutrition, increase skin elasticity, anti-aging and anti-wrinkle. |
| Lotion, cream | 6-14×105 Dalton | 0.1% | Tighten the skin, preserve moisture for long time |
| Sunscreen | ≥14×105 Dalton | 0.1%~0.5% |
Form a breathable film on the surface of the skin, which makes the skin smooth and moist, also can prevent skin from the invasion of foreign bacteria, dust and UV. |
| By Express | By Air | By Sea |
|---|---|---|
| Suitable for under 50kg Fast: 7-15 days High cost Door to door service easy to pick up the goods |
Suitable for more than 50kg Fast: 7-15 days High cost Port to port professional broker needed |
Suitable for more than 500kg Slow: 7-45 days Low cost Port to port professional broker needed |
| Paypal(Suitable for under 500USD) | Alipay | Bank Transfer(Suitable for all amount) |
|---|---|---|
| 15% charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time:2-3 work days Easy to handle |
With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
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