Camptothecin (CPT) is an alkaloid isolated from the the bark and stem wood of the Chinese tree, Camptotheca acuminate. CPT showed remarkable anticancer activity in preliminary clinical trials but also severe side effects, which limits its usefulness in patients. Currently, two semi-synthetic derivatives of camptothecin, topotecan and irinotecan, which retain anti-cancer activity but with less severe side effects, are used to treat a variety of cancers.
| Active ingredient: | Camptothecin | CAS Number: | 7689-03-4 |
| Molecular formula: | C20H16N2O4 | Molecular weight: | 348.36 |
| Molecular structure: |  |
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Xi shu (botanical name Camptotheca acuminata) belongs to the Nyssaceae family and is a huge tree growing up to a height of 25 meters having thin reddish-brown bark and a small number of branches close to its apex. This tree produces shiny green, leathery leaves, while the small, white flowers have curved heads.
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Analysis |
Quality Standard |
Test Results |
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CHARACTERISTICS
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Pale yellow needle crystalline powder; decompose with exposed to light, slightly hygroscopic.
Soluble in chloroform, very slightly soluble in methanol or ethanol, practically insoluble in water, soluble in dilute alkali solution.
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Conform
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IDENTIFICATIONS
(1). 4 mg/ml chloroform solution
(2). 4 mg/ml 1% NaOH solution
(3). 5 mg/ml methanol solution
(4). IR spectrum
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Blue violet fluorescence color under 365 nm.
A pale yellow color solution, appears violet fluorescence color under 365 nm.
Maximum absorptions at 254 nm and 372 nm.
Same as the reference spectrum No. 857.
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Positive reaction
Positive reaction
Conform
Conform
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TESTS |
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Solubility in CHCl3-CH3OH |
Clear solution |
Clear solution |
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Loss on drying |
≤1.0% |
0.29% |
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Melting Point |
275-277°C |
Conform |
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Max. impurity before the principle peak |
≤0.50% |
0.42% |
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Max. impurity after the principle peak |
≤0.50% |
0.31% |
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Purity, by HPLC |
≥99.0% |
99.65% |
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Assay, by HPLC on dried substance |
≥99.0% |
99.80% |
| By Express | By Air | By Sea |
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| Suitable for under 50kg Fast: 7-15 days High cost Door to door service easy to pick up the goods |
Suitable for more than 50kg Fast: 7-15 days High cost Port to port professional broker needed |
Suitable for more than 500kg Slow: 7-45 days Low cost Port to port professional broker needed |
| Paypal(Suitable for under 500USD) | Alipay | Bank Transfer(Suitable for all amount) |
|---|---|---|
| 15% charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time: immediately Easy to handle |
Reasonable bank charges Arrive time:2-3 work days Easy to handle |
With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.
Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.
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